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General Clinical Research Center

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#TitlePrimary Investigator
241Structural Functional Relationships in Diabetic Nephropathy Mauer, Michael
245Epidemiology of Diabetes Interventions and Complications Trial (EDIC) Bantle, John
284Endocrine Pancreatic Function in Recipients of Pancreas Islet Tx Seaquist, Elizabeth
415Genetic Epidemiology of Chronic/Recurrent Otitis Media Daly, Kathleen
449The Identification of Factors Predisposing Diabetic Patients to Nephropathy Mauer, Michael
482NMR Studies of Human Brain Glucose MetabolismSeaquist, Elizabeth
508In Vivo Magnetic Resonance Studies of Glucose Metabolism in Humans at 4 Tesla using 13C Labeled Glucose Infusions Seaquist, Elizabeth
629Renal and Cellular Studies in Type I Diabetic Patients Mauer, Michael
688Angiotensin II Receptor Blockade in the Prevention of Interstitial ExpansionIbrahim, Hassan
695Action to Control Cardiovascular Risk in Diabetes (ACCORD) Seaquist, Elizabeth
826White Matter Abnormalities in SchizophreniaLim, Kelvin
827fMRI Studies of Single-Noun Processing SchizophreniaPardo, Jose
828Nociception in Bulimia NervosaFaris, Patricia
857Investigation of the Genetics of AsthmaBlumenthal, Malcolm
870NMR Measurements of Human Brain Glycogen MetabolismSeaquist, Elizabeth
874Alopecia Areata Registry and Immunogenetic MechanismsHordinsky, Maria
901Genotypic Influences on Prefrontally-guided Behaviors in AdolescentsLuciana, Monica
911Project 2: Effect of Aging on Glucuronidation of Antiepileptic Drugs Remmel, Rory
912MT2003-23:Non-Myeloblative Haploidentical HSCT with NK Cell Infusions in High Risk Myeloid MalignanciesCooley, Sarah
956Clinical Outcome Measures in Friedreich's AtaxiaBushara, Khalaf
961The Type 1 Diabetes Genetics ConsortiumMoran, Antoinette
971Neuroendocrine Functions in Post-Institutionalized ChildrenJohnson, Dana
976Neurodevelopmental Effects of Fetal Alcohol ExposureWozniak, Jeffrey
991Phase II Study of Combined Laronidase (Aldurazyme) Enzyme Replacement Therapy (ERT) with Hematopoietic Stem Cell Transplantation (HSCT) for Hurler Syndrome (MPS IH)Orchard, Paul
996Metabolic Outcome after Islet Transplantation in T1DM: A Pilot StudyMoran, Antoinette
1018Cerebral Responses to Insulin-Induced Hypoglycemia-Aims 1 & 2Seaquist, Elizabeth
1023Neuroanatomical and Biochemical Correlates of Low Back PainBeebe, David
1042Metabolic Syndrome in Childhood Cancer SurvivorsSteinberger, Julia
1047Preventing Neutralizing Antibody Formation in MS Patients with sc IFN-beta (Rebif)Parry, Gareth
1050CNS Degeneration in Myotonic Dystrophy Types 1 and 2Day, John
1053White Matter Structure/Function in DiabetesSeaquist, Elizabeth
1056Newborn Iron Deficiency (Treatment)Georgieff, Michael
1057Brain Metabolism in Patients Undergoing Weight-Reduction SurgeryPardo, Jose
1062Assessing Long Term Outcomes of Living DonationKasiske, Bert
1064Development of Auditory Memory in Newborn InfantsTherien, Jill
1068Smokeless Tobacco Products vs. Medicinal Nicotine: Pharmacokinetics and Pharmacodynamics in HumansHatsukami, Dorothy
1079MT2005-08-Allogeneic Natural Killer Cells in Patients with Advanced Metastatic Breast Cancer Cooley, Sarah
1082Proteomic Analysis of Cerebrospinal Fluid (CSF) in Patients with Hereditary Ataxia for Purpose of Disease Marker Identification and DiagnosisBushara, Khalaf
1085Sensitivity of Diffusion Tensor Imaging (DTI) in Mild to Moderatel Pediatric Traumatic Brain Injury (TBI)Wozniak, Jeffrey
1087MT2005-14-Phase I Open Label, Single Arm, Dose Escalation Trial to Evaluate the Biodistribution and Safety of AHN-12 in Patients with Advanced LymphomaBurns, Linda
1088MT2005-13-A Phase I Open Label, Single Arm, Dose Escalation Trial to Evaluate the Biodistribution and Safety of AHN-12 in Patients with Advanced LeukemiaBurns, Linda
1089Paroxetine Effect on Response to Mental Stress During Cigarette SmokingKotlyar, Michael
1111Neurocognitive Outcomes of Infants of Diabetic MothersThomas, Kathleen
1125Diagnostic Prostate Magnetic Resonance Imaging at 3 Tesla with an Endorectal CoilMetzger, Greg
1128A Phase I/II Study of NB1011 Administered Intravenously by Continuous Infusion in an Every Second Week Regimen with Open Label Continuation in Cancers that Overexpress the Enzyme Thymidylate SyntaseDudek, Arkadiusz
1132Effect of Aging on Glucuronidation of Antiepileptic Drugs-Lamotrigine (Lamictal)Remmel, Rory
1138Bone Mineral Resorption in Children after Hematopoietic Cell TransplantationPolgreen, Lynda
1149Genomics of Kidney TransplantationJacobson, Pamala
1150CIT-03: Single-Center, Open-Label Clinical Trial of the Efficacy of Peritransplant Administration of Deoxyspergualin in Promoting Restoration of Insulin Independence After Single-Donor Islet Allotransplantation in Non-Uremic Type 1 Diabetic Recipients Hering, Bernhard
1151CIT-07: Islet Transplantation in Type 1 DiabetesHering, Bernhard
1154Effect of Estradiol and Testosterone on Brain Activation Patterns in Postmenopausal Women Utilizing Functional Magnetic Resonance ImagingArcher, Johanna
1155Cannabis and SchizophreniaKumra, Sanjiv
1162Assessment of Brain Iron in Parkinson's Disease by T2p and T1p MRITuite, Paul
1166Deficits in Perceptual Organization and Thought Disorder in Schizophrenia, fMRI, MRSMilev, Peter
1168Magnetic Resonance Spectroscopy of Focal Dystonia at 7 TeslaTuite, Paul
1174rTMS as a Treatment for Focal Hand DystoniaKimberley, Teresa
1176Cardiovascular Risk and Insulin Resistance: Ages 7-40Steinberger, Julia
1178Measurement of Glucose in Human Brain by NMR: The Effect of Islet Cell TransplantationSeaquist, Elizabeth
1179CIT-06: Islet Transplantation Versus Standard Medical Therapy in Type 1 Diabetic Kidney Allograft RecipientsHering, Bernhard
1181Effects of Rituximab on the Progression of Type 1 Diabetes in New Onset SubjectsWagner, John
1189Determinants of Exercise Capacity in Normal Healthy SubjectsPainter, Trish
1191Breast Cancer Susceptibility: A Possible Role for Nucleotide Excision RepairGross, Myron
1197Prospective Study of Outcomes Following Pancreatectomy and Autologous Islet Transplantation for Treatment of Pancreatic DiseaseSutherland, David
1200Phase I Clinical Trial of Trametes Versicolor in Women with Breast CancerTorkelson, Carolyn
1203Obesity Development During Treatment of Parkinson's DiseaseBillington, Charles
1206MT2007-16R-Pilot Study of Vascular Function During Hematopoietic Cell TransplantationSmith, Angela
1209The Study of Acid Reflux in Children with AsthmaBlumenthal, Malcolm
1211Computational Modeling of High Field MR ImagesLim, Kelvin
1214Diabetes Surgery StudyIkramuddin, Sayeed
1218Effect of Antithymocyte Globulin on Preserving Beta-cell Function in New Onset Type 1 Diabetes MellitusMoran, Antoinette
1219Evaluation of Intramyocellular Lipid Content in Skeletal Muscle by Magnetic Resonance SpectroscopyChow, Lisa
1220Collection of Control Blood Samples for Diet and Hormone StudiesKurzer, Mindy
1221Nutritional Status, Physical Growth, and Neurodevelopment in International AdopteesGeorgieff, Michael
1225In Vivo 1H NMR Spectroscopy of HD/1H NMR Spectroscopy of Early HDDubinsky, Janet
1226Six Weeks vs. Six Months of Valganciclovir in Infants with Symptomatic Congenital CMVHan, Jin-Young
1229The Genetic Basis of CFRDMoran, Antoinette
1230The Autoimmune Basis of CFRDMoran, Antoinette
1231Etiology of Childhood ObesityLytle, Leslie
1232Magnetic Resonance Imaging of the Prostate at 7 TeslaMetzger, Greg
1233Osiris Protocol #603: A Phase III, Multicenter, Placebo-Controlled, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Study Drug Intravenous Infusion for the Induction of Remission in Subjects Experiencing Treatment-Refractory Moderate-to-Severe Crohn's DiseaseKhoruts, Alexander
1234MT2006-09: Phase 1, Open Label, Single Arm, Dose Escalatoin Trial to Evaluate the Biodistribution and Safety of BU-12 in Patients with Avanced LeukemiaWeigel, Brenda
1239The Effect of rTMS-induced Cortical Inhibition on Visuospatial Motor Sskill AcquisitionKimberley, Teresa
1240Determining and Comparing the Pharmacokinetics of [D10]Phe in Smokers After Oral Dosing and Incorporation into Cigarettes (part of Benzo[a]pyrene Metabolism: Phenotyping and Genotyping)Hecht, Stephen
1242Compartmental Analysis of HIV Reservoirs and Immune Reconstitution: Protocols A, B and CSchacker, Timothy
1243The Impact of Genetic Determinants of Fenofibrate's Pharmacogenetics on Lipid ResponseStraka, Robert
1245Eli Lilly #F1K-MC-EVDK: A Phase 2 Study to Evaluate Dose and Duration of Treatment of Drotrecogin Alfa (Activated) Using Serial Measurements of Protein C in Patients with Severe Sepsis and Multiple Organ DysfunctionManshaii, Sapoora
1246Neurocognitive and White Matter Changes in Adult Hematopoietic Cell Transplant SurvivorsMajhail MD, Navneet
1247MT2007-12: Allogeneic Natural Killer Cells with Rituximab in Patients with CD20 Positive Relapsed Non-Hodgkin Lymphoma or Chronic Lymphocytic LeukemiaBachanova, Veronika
1250Functional Imaging of Trigeminal Neuropathic PainNixdorf, Donald
1251Assessment of Endothelial Function and Peripheral Circulation in Cardiac Transplant PatientsTempleton, Danielle
1254The Development and Functional Neural Network of Flexible Rule UseHongwanishkul, Donaya
1255Baclofen Efficacy and Safety Trials-Pharmacokinetic/Pharmacodynamic PhaseKrach, Linda
1256Lipid Infusion Effects on Skeletal Muscle Fatty Acid Metabolites and Mitochondrial FunctionChow, Lisa
1263Pfizer A4021012: A Phase I Pharmacodynamic Study of CP-751,871 as Neoadjuvant Treatment for Early Breast Cancer Yee, Douglas
1265Breast MRI Assessment of Tumor Viability After Radio Frequency Ablation (RFA)Tuttle, Todd
1271Effects of CTLA-4IG (Abatacept) on the Progression of Type 1 Diabetes in New Onset SubjectsMoran, Antoinette
1273Leukocyte Adhesion in Allergic Inflammation/Serotonin (5-HT) and 5-HT2A in Allergic InflammationBlumenthal, Malcolm
1282The Effect of Childhood Obesity on Phase 1 and Phase 2 Drug Metabolism EnzymesJohnson, L'Aurelle
10008Magnetic Resonance Spectroscopy of Parkinson's Disease at 7 TeslaTuite, Paul
10009Assessment of Endothelial Function and Peripheral Circulation in Patients with Left Ventricular Assisted Device (LVAD) Support (Pilot)Templeton, Danielle
10012Exercise Training to Reduce Claudication: Arm Ergometry Versus Treadmill TrainingTreat-Jacobson, Diane
10013Noninvasive Evaluation of Cardiac Allograft Vasculopathy in Recipients within Five Years of Heart TransplantColvin-Adams, Monica
10017Biological and Cultural Factors Associated with Lactational Dysfunction in Overweight WomenHauff, Laura
10022Longitudinal Study of Adiabatic T1rho and T2rho Methods in Parkinson's DiseaseTuite, Paul
10023Growth in Preterm Infants Receiving Nutrient Intakes Approximating Fetal IntakesGeorgieff, Michael
10024Neural Correlates of Essential TremorBushara, Khalaf
10027Recovery from Early Life Stress in Children Adopted from InstitutionsGunnar, Megan
10031Response to Smoking Cues Presented in a Virtual Reality EnvironmentKotlyar, Michael
10032Phase 1 Study of Sorafenib, Pemetrexed, and Cisplatin for the Treatment of Advanced Solid TumorsKumar, Priya
10035A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of PROCHYMAL (Ex Vivo Cultured Adult Human Mesenchymal Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)Moran, Antoinette
10037Clinical and Neuropsychological Correlates of Nailfold Plexus Visibility in SchizophreniaVuchetich, John
10038Phase II/III, Randomized, Clinical Trial of the Effects of Nutropin AQ on Growth and Bone Metabolism in Children With MPS I, II, and VI and Short StaturePolgreen, Lynda
10039Green Tea and Reduction of Breast Cancer RiskKurzer, Mindy
10041Weight Loss and Biological Parameters in Breast Cancer SurvivorsKurzer, Mindy
10043PreSEPT Colorectal Cancer Screening StudyChurch, Timothy R.
10044Genetics of Diabetic Nephropathy (DN)Mauer, Michael
10046Pharmacogenetics RegistryTracy, Tim
10047Human Laboratory Study of Varenicline and Bupropion for Nicotine DependenceMooney, Marc
10052Development of Affective Processing in Adolescents with Major Depressive DisorderCullen, Kathryn
10053Exercise or Relaxation for Smoking Cessation in Postmenopausal SmokersAllen, Sharon
10054Comprehensive Support for Alzheimer's Disease CaregiversGaugler , Joseph
10057Psychopathology and Intercital Discharges in Children with EpilepsyPotegal, Michael
10061Pharmacogenetics of Warfarin Induction and InhibitionTracy, Tim
10062Biomarkers of Airway Injury and Remodeling in Pediatric Cystic FibrosisLaguna, Terri
10064Decay Kinetics of HIV with the Integrase Inhibitor RaltegravirSchacker, Timothy
10065Pioglitazone Therapy in Obese Children with Insulin Resistance: A Randomized, Controlled Pilot StudyKelly, Aaron
10066Acute Effects of Bioactive Peptides on the Renin-Angiotensin System in Overweight Men: Pilot Study Phase IEarthman, Carrie
10067Minnesota Infant Nutrition, Neurodevelopment, and Obesity Study (MINNOwS): Premature Infant Pilot StudyDemerath, Ellen
10069Safety and Efficacy of Botulinum Toxin Injections in the Treatment of Psoriasis VulgarisDykstra, Dennis
10070Endogenous Opiates and Stress Responseal'Absi, Mustafa
10071Novel MRI Methods for Neuronal Loss and Iron Quantification in Parkinson's DiseaseMichaeli, Shalom
10072DISTOL-1: Digital Ischemic Lesions in Scleroderma Treated with Oral Treprostinil Diethanolamine: A Randomized, Double-Blind, Placebo-Controlled, Multicenter StudyMolitor, Jerry
10074Two Stage Genome-Wide Association Study in Systemic SclerosisMolitor, Jerry
10076Genzyme GC100801208: Expanded Access Use of GC1008 in a Single Patient with Progressing Idiopathic Pulmonary FibrosisWhelan, Timothy
10078Effects of Genotype on CYP2C9 Drug InteractionsTracy, Tim
10081GLP-1 Therapy for Weight Loss and Improved Glucose Tolerance in Obese Children: A Randomized, Controlled, Pilot StudyKelly, Aaron
10082A Phase 2, Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Study Evaluating the Efficacy and Safety of CNTO 888 Administered Intravenously in Subjects with Idiopathic Pulmonary FibrosisWhelan, Timothy
10085Contrasting the Brain Effects of Risperdal and INVEGA with Functional MRI ScanningLim, Kelvin
10087Cross-Sectional Study of the Effect of Naltrexone on Cerebral Blood Flow and Hypoglycemia in Type 1 DiabetesSeaquist, Elizabeth
10090The United Dystrophinopathy ProjectDay, John
10094The Imprinting and Methylation Patterns after ART (IMPART) StudySpector, Logan
10096A Phase 2b Extension Study of PTC124 in Subjects with Nonsense-Mutation Mediated Duchenne and Becker Muscular DystrophyDay, John
10100PAL-003: Long-Term Extension of A Phase 2, Open-Label Dose-Finding Study to Evaluate the Safety, Efficacy, and Tolerability of Multiple Subcutaneous Doses of rAvPAL-PEG in Subjects with PKUWhitley, Chester
10101Musculoskeletal and Cardiovascular Health Following Bariatric SurgeryPetit, Moira
10103DISTOL-EXT: Digital Ischemic Lesions in Scleroderma Treated with Oral Treprostinil Diethanolamine: An Open Label Multicenter Extension StudyMolitor, Jerry
10104How Exercise and Relaxation Techniques Impact Endothelium in WomenLindquist, Ruth
10105Relation of Oxidative Stress to Insulin Resistance, Insulin Secretion and ObesityFrohnert, Brigette
10107A Phase 2, Randomized, Multicenter, Placebo-Controlled, Double-Blind, Parallel-Group Study to Evaluate the Efficacy, Safety, and Population Pharmacokinetics of Once-Daily Oral E5501 Tablets Used Up to 7 Days in Subjects with Chronic Liver Diseases and Thrombocytopenia Prior to Elective Surgical or Diagnostic ProceduresLake, John
10108Diabetic Kidney Disease: Influence of Exercise on Physical and Vascular FunctionBronas, Ulf
10109An Open-Label, Randomized Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab (TCZ) Monotherapy or TCZ in Combination with Nonbiologic DMARDs in Patients with Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Nonbiologic or Biologic DMARDSMolitor, Jerry
10111Longitudinal Studies of Brain Structure and Function in MPS Disorders (A Longitudinal Study of the Lysomal Disease Network)Shapiro, Elsa
10113NON-CTSI PROTOCOL: Hypothalamic-Pituitary-Adrenal Axis Stress Responses in Small for Gestational Age InfantsOsterholm, Erin
10114A Longitudinal Study of Bone and Endocrine Disease in Children with MPS VI: A Longitudinal Study of the Lysosomal Disease NetworkPolgreen, Lynda
10115Diabetes and Periodontal Therapy TrialMichalowicz, Bryan
10116Feasibility of Aerobic Exercise in Alzheimer's DiseaseYu, Fang
10117Phase II, Multicenter, Open-Label, Single arm Trial to Evaluate the Safety and Efficacy of Oral E7080 in Medullary and Iodine-131 Refractory, Unresectable Differentiated Thyroid Cancers, Stratified by HistologyBurmeister, Lynn
10135Phase II, Randomized, Double Blind, Placebo Controlled Trial of PEITC as a Modifier of NNK Metabolism in SmokersYuan, Jian-Min
10136Effects of Alcohol Consumption on Levels of Acetaldehyde-Derived Adducts in DNA from Human Buccal Cells and Peripheral Blood Nucleated CellsHecht, Stephen
10137HPN-100-1007: A Phase 3, Open-Label Study of the Safety of HPN-100 for the Long-Term Treatment of Urea Cycle Disorders (Treat UCD)Berry, Susan
10145Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers-Study 1: Preference, Health Effects adn Efficacy of Five Oral Tobacco Products Hatsukami, Dorothy
10146Bupropion + Placebo or Bupropion + Naltrexone for Smoking CessationMooney, Marc
10147Innovative Interventions for Smoking Cessation: Comparison of Nicotine-free Cigarettes Plus Nicotine Patch; Nicotine Cigarettes Alone or Nicotine Patch AloneHatsukami, Dorothy
10148Novel Determinants and Measures of Smokeless Tobacco Use: Study 1-Toxicant Exposure Across Brands of Smokeless TobaccoHatsukami, Dorothy
10149Combination Therapy with Varenicline and Bupropion for Smoking CessationHatsukami, Dorothy
10150A Pilot Study to Evaluate the Effects of Purple Grape Juice on the Vascular Health of Childhood Cancer Survivors aka The Juice and Vascular Assessment (JAVA) StudyBlair, Cindy
10151A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of HPN-100 for Maintaining Remission in Subjects with Cirrhosis and Episodic Hepatic Encephalopathy (HALT-HE)Stewart, Charmaine
10152Neural Correlates of Food Reward in American Indian WomenBeckman, Tiffany
10153A Study of a Topical Formulation of Nitroglycerin, Vascana (VASCANA), and Matching Vehicle in the Treatment and Prevention of Symptoms Associated with Raynaud's PhenomenonMolitor, Jerry
10157Pediatric Hemiparesis: Synergistic Treatment Using rTMS and CITCarey, James
10161Human Laboratory Study of Smokeless Tobacco ProductsMooney, Marc
10162A Phase 2a Study of Ataluren (PTC124) in Nonambulatory Patients with Nonsense-Mutation-Mediated Duchenne/Becker Muscular DystrophyDay, John

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